Bipolar disorder (BD) is a psychiatric illness associated with high morbidity, mortality and suicidal rate. It has neuroprogressive course and a high rate of treatment resistance. Bipolar disorder is a burdensome and recurrent psychiatric condition that affects more than 1% of the population, and has the highest risk of suicide among all psychiatric disorders. Research has shown that most patients experience depression for a significant part their lives. The treatment failure rates of bipolar depression are higher than those of major depression disorder (MDD). A longer duration of bipolar disorder leads to neuroprogression which involves structural brain changes and neuropsychological deficits. Currently, there is an unmet options for both short-…