• Autoimmune diseases

    Nuclear Factor-Kappa B (NF-kB)

    Nuclear factor-kappa B (NF-kB) is a transcription factor that plays critical functional roles in inflammation, immunity, cell proliferation, differentiation, and survival. It exists in an inactive state in the cytosol and can be stimulated by molecules such as TNF╬▒, and other cell stressors. NF-kB is found in almost all cellular cell types and is identified as a regulator of kB light chain expression in mature B and plasma cells. Because NF-kB has the ability to influence the expression of numerous genes, its activity is tightly regulated at multiple levels. The primary mechanism for regulating NF-kB is through inhibitory IkB proteins and the IKK complex, which phosphorylates IkBs. Nuclear Factor-kappa B…