• Autoimmune diseases

    LUPUS

    Systemic Lupus erythematosus (SLE) or simply, Lupus is a chronic inflammatory and autoimmune disease with a wide range of clinical presentations resulting from its effect on multiple organs and systems. Patients with SLE experience a loss of self tolerance. This is because of abnormal immunological function and the production of auto-antibodies; thus, leading to the formation of immune complexes that may have adverse effects on healthy tissues. Most patients also experience periodic flares of varying severity or instances in which no observable signs or symptoms are present. Abnormal innate immune responses play significant role in the pathogenesis of SLE. They lead to tissue injury through the release of inflammatory cytokines…

  • Autoimmune diseases

    What is the Mechanism of Action of Corticosteroid?

      Corticosteroid is synthetic drug that mimic the adrenal hormone, cortisol, used in the management of many inflammatory and autoimmune health conditions. They modify the functions of epidermal and dermal cells and of leukocytes involved in proliferative and inflammatory diseases of the skin. Corticosteroids can be used in treating several health conditions, such as: Asthma Allergies Eczema Hives Psoriasis Chronic obstructive pulmonary disease Gout Lupus Multiple sclerosis Autoimmune diseases Types of corticosteroids Corticosteroids come in different forms. Some of the corticosteroids used in treating inflammations include cortisone, prednisone and methylprednisolone. Prednisone is the most commonly used type of steroids used in treating certain rheumatoid diseases like rheumatoid arthritis or lupus.…