• Roles-of-MMPs-in-tumor-cell-metastasis-The-roles-of-MMPs-in-metastasis-are-multifold.
    Autoimmune diseases

    Matrix Metalloproteinases (MMPs)

    Matrix metalloproteinases (MMPs) are a family of Zinc-dependent endopeptidase that degrade various proteins of the extracellular matrix (ECM). As members of the metzincin group of proteases, they share the conserved zinc-binding motif in their catalytic active site. Initially, MMPs were thought to function mainly in degrading ECM, but recent studies has shown that they also function significantly as regulators of extracellular tissue signaling networks. MMPs are defined by the presence of two conserved zinc-binding motifs. One motif is a cysteine-containing pro-domain, whose function is partly to restrain catalytic; whereas the other motif is a histidine-rich catalytic domain, responsible for the endopeptidase activity. MMPs Are Involved in Various Physiological and Pathological…