• Autoimmune diseases

    Role of HBx protein in hepatocellular carcinoma (HCC)

    Hepatitis B virus X (HBX) protein is a multifunctional viral protein that regulates different cellular processes such as the modulation of protein degradation pathways, transcription, apoptosis, signal transduction, cell cycle, and genetic stability, by interacting with the host factors either directly, or indirectly. HBx is known to play a major role in the pathogenesis of viral induced hepatocellular carcinoma (HCC). The carboxy terminal of HBx has been shown to likely play a role in protein-protein interactions, transcriptional transactivation, DNA repair, cell, signaling and pathogenesis of HCC. HBx protein structural and functional relationship HBx is a 154-amino acid regulatory protein with a molecular mass of approximately 17 kDa. The X-protein consists…