• Autoimmune diseases

    LUPUS

    Systemic Lupus erythematosus (SLE) or simply, Lupus is a chronic inflammatory and autoimmune disease with a wide range of clinical presentations resulting from its effect on multiple organs and systems. Patients with SLE experience a loss of self tolerance. This is because of abnormal immunological function and the production of auto-antibodies; thus, leading to the formation of immune complexes that may have adverse effects on healthy tissues. Most patients also experience periodic flares of varying severity or instances in which no observable signs or symptoms are present. Abnormal innate immune responses play significant role in the pathogenesis of SLE. They lead to tissue injury through the release of inflammatory cytokines…